Tetracycline — Uses, Dose, Side Effects and How to Stay Safe
Tetracycline is an older antibiotic that still works for many bacterial infections. You’ll see it used for acne, respiratory infections, some sexually transmitted infections, and certain skin or soft-tissue problems. It belongs to the tetracycline family (along with doxycycline and minocycline), and it stops bacteria from making proteins they need to grow.
Knowing when and how to take tetracycline helps you get the best result and avoid common problems. Below are the practical facts you want before you take it.
How it’s used and typical dosing
For most adults, oral tetracycline comes as 250–500 mg taken every 6 hours (four times a day) depending on the infection. Some skin or acne regimens use lower daily doses for longer periods. Doctors adjust dose for kidney problems, so tell your prescriber if you have reduced kidney function. Always follow the exact dose and length your clinician prescribes — stopping early can let the infection return.
Take each dose with a full glass of water and avoid lying down right after. Don’t take tetracycline with dairy, calcium supplements, iron pills, antacids, or bismuth within two hours — these bind the drug and cut its absorption.
Side effects, risks, and interactions
The most common complaints are nausea, stomach upset, and diarrhea. Take with food if your stomach protests, but avoid dairy at the same time. Tetracycline makes your skin more sensitive to sunlight — use sunscreen and cover up to prevent severe sunburn.
Do not give tetracycline to pregnant people or children under eight years old. It permanently discolors growing teeth and can affect bone growth. There’s also a small risk of increased pressure in the skull (headaches, vision changes) — report persistent headaches or vision problems right away.
Tetracycline can interact with several drugs. It may reduce the effectiveness of oral contraceptives, and antacids or iron supplements reduce its blood levels. It may also raise the risk of yeast or C. difficile infections. Always list all medicines you take to your prescriber.
Storage is simple: keep tablets in a cool, dry place away from direct heat and sunlight. Finish the full course unless your doctor tells you otherwise, even if you feel better in a few days. If you miss a dose, take it as soon as you remember unless the next dose is near—don’t double up.
Questions for your doctor: is this the best antibiotic for my infection, do I need kidney dose changes, and should I avoid other meds or supplements while taking this? If you notice severe allergic reactions (rash, swelling, trouble breathing), stop and seek emergency care.
Knowing the basics — proper timing, interactions, and safety warnings — keeps tetracycline effective and lowers risks. If anything feels off while you’re on it, contact your healthcare provider for advice.